5-Aminotetrazole monohydrate

Preparation of 5-aminotetrazole monohydrate (AT) by treating dicyandiamide with sodium azide in acidic medium at 65 °C. 

Aminotetrazole monohydrate is available from Aldrich Chemical Company, Inc. it was dehydrated by heating over P205 at 100°C under reduced pressure (100 p.) for 4 hr. 

For 1-methyltetrazole in dichlorobis(l-methyltetrazole)zinc(II) (711C661). For 5-aminotetrazole monohydrate (67AX30s). 

A mixt of 50g of aminotetrazole monohydrate, 19.1g of Na hydroxide, and 97ml of w is heated to 92—95°, and 31,7g of dimethyl sulfate is added dropwise over 40 mins. The temp of the reaction mixt is held at 96° for an additional hour and then cooled to 5° overnight. The product, l-methyl-5-aminotetrazole, is removed by filtration, washed with cold w, and dried to yield 24.2g... 

Summary 5-Aminotetrazole is prepared by reacting hydrazine monohydrate with hydrochloric acid, and calcium cyanamide solution. Afterwards, hydrochloric acid and sodium hydroxide are added, and then the mixture is heated. Afterwards, the mixture is cooled, and upon cooling, the 5-aminotetrazole precipitates. It is then collected by vacuum filtration. Commercial Industrial note For related, or similar information, see Application No. 392,308, February 22, 1995, by Nippon Carbide Kogyo Kabushiki Kaisha, Tokyo, JP, to Masahiro Murotani, Toyama, JP, Hajime Mura, Uozu, JP, Makoto Takeda, Takaoka, JP, and Hiroshi Shibafuchi, Uozu, JP. Part or parts of this laboratory process may be protected by international, and/or commercial/industrial processes. Before using this process to legally manufacture the mentioned compound, with intent to sell, consult any protected commercial or industrial processes related to, similar to, or additional to, the process discussed in this procedure. This process may be used to legally prepare the mentioned compound for laboratory, educational, or research purposes. 

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