Aminoglycosides physicochemical properties

During a study of the physicochemical properties of some aminoglycoside antibiotics Kuzyaeval- - determined the static and dynamic exchange capacities of neomycin on the cation exchange resin KB-4P-2(a phenoxyacetic ac. d-f ormaldehyde resin) using the resin in the Na form. [Pg.414]

The chemical nature and related physicochemical properties largely govern the distribution and elimination, which refers to biotransformation (metabolism) and excretion, of antimicrobial agents. The majority of antimicrobial agents are weak organic electrolytes, either weak acids (penicillins, cephalosporins, sulphonamides) or weak bases (aminoglycosides, lincosamides, macrolides, diaminopyrimidines, metronidazole), while fluoroquinolones, tetracyclines and rifampin are amphoteric compounds, and chloramphenicol and its... [Pg.217]

The papers given at a symposium on aminocyclitol antibiotics have been published most are reports of the synthesis of naturally occurring compounds or their conversion to modified analogues in search of improved antibiotic activity. A review has also appeared covering the structure, physicochemical and biological properties, structure-activity relationships, and mode of action of aminoglycoside antibiotics. ... [Pg.152]

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