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Resistance aminoglycoside antibiotics

Smith CA, Baker EN (2002) Aminoglycoside antibiotic resistance by enzymatic deactivation. Curr Drug Targets Infect Disord 2 143-160... [Pg.775]

Hon WC, McKay GA, Thompson PR, Sweet RM, Yang DS, Wright GD, Berghuis AM. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. Cell 1997 89 887-895. [Pg.100]

The success of dibekacin prompted worldwide attention to the removal of selected OH groups in aminoglycoside antibiotics susceptible to modification by resistant bacteria, and the chemical deoxygenation procedure of D. H. R. Barton was found particularly useful. [Pg.12]

Further studies on the mechanism of resistance of aminoglycoside antibiotics focused on resistance genes existing in antibiotic-producer strains (mainly by Drs. Y. Okami and Kunimoto Hotta), and gradually clarified the relationship between the antibiotic-producing and -regulating mechanism. During this search, indolizomycin (1984) was discovered by cell fusion of two kinds of strains. [Pg.12]

Biochemical mechanism of resistance to aminoglycosidic antibiotics, H. Umezawa, Adv. Carbohydr. Chem. Biochem., 30 (1974) 183-225. [Pg.20]

White L.O. Reeves D.S. (1983) Enzymatic assay of aminoglycoside antibiotics. In Antibiotics Assessment of Antimicrobial Activity and Resistance (eds A.D. Russell L.B. Quesnel), pp. 199-210. Society for Applied Bacteriology Technical Series No. 18. London Academic Press. [Pg.491]

Wright GD, Berghuis AM, Mobashery S Aminoglycoside antibiotics. Structures, functions, and resistance. Adv Exp Med Biol 1998,456 27-69. [Pg.60]

Development of resistance to rifaximin is primarily due to a chromosomal one-step alteration in the drug target, DNA-dependent RNA polymerase. This differs from the plasmid-mediated resistance commonly acquired by bacteria to aminoglycoside antibiotics such as neomycin... [Pg.71]

Structure and Flexibility of Aminoglycoside Antibiotics Bound to Enzymes Involved in Bacterial Resistance... [Pg.126]

Vicens, Q. Westhof, E., Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes An analysis of x-ray crystal stmctures. [Pg.41]

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Aminoglycoside antibiotics resistance, enzymatic mechanism

Aminoglycoside antibiotics, resistance mechanism

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