1-Aminobenzotriazole, cytochrome inhibitor

As total inhibitors of the P450 enzyme family, 1-Aminobenzotriazole (Lee and Slattery 1997) and Proadifen (SKF525A) (Lee et al. 1998) are suitable to distinguish from non-cytochrome P450 mediated pathways. 

An inhibiting chemical slows the enzymatic metabolism of a toxic chemical. In this instance, if the uptaken chemical itself is the toxin, inhibition will slow the metabolism and intensify its action. If the metabolite of the absorbed xenobiotic is the toxic agent, inhibition will decrease the toxic affect. Vinyl chloride uptake in rats results in the lowering of cytochrome P450 and a corresponding loss of ability to metabolize other xenobiotics. Other inhibitors include diethyl maleate, which inhibits glutathione s-transferase and 1-aminobenzotriazole, which inhibits P450. 

Mathews, J.M. and J.R. Bend (1993). N-Aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome P450 in vivo. J. Pharmacol. Exp. Then 265, 281—285. 

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