4- Aminobenzoic acid butyl ester

Synonyms 4-Aminobenzoic acid butyl ester butylaminobenzoate ... 

Synonyms cas 94-25-7 p-aminobenzoate acid butyl ester butamben... 

Aminobenzoic acid, butyl ester. See Butyl anthraniiate... 

Synonyms 2-Aminobenzoic acid, butyl ester Benzoic acid, 2-amino-, butyl ester Butyl-2-aminobenzoate Butyl-o-aminobenzoate n-Butyl anthranilate... 

CAS 94-25-7 EINECS/ELINCS 202-317-1 Synonyms 4-Aminobenzoic acid, n-butyl ester p-Aminobenzoic acid, butyl ester Benzoic... 

A variety of reagents have been described for reductive amination, a labelhng reaction based on the attachment of an amino group at the carbonyl group in a reducing sugar under mild acidic conditions. This yields an acid-labile Schiff base (imine derivative), which is subsequently reduced to a stable secondary amine. Frequently applied reagents are 2-aminopyridine (PA), 2-aminoacridone (2-AMAC), and 4-aminobenzene derivatives such as 4-aminobenzoic ethyl ester (ABEE) or aminobenzoic butyl ester (ABBE). 

For the synthesis of the AMT ester (VIII.151), bromide (VIII. 156)-HBr was condensed in situ with 4-aminobenzoic acid and the product, 4-amino-4-deoxypteroic acid (APA), was treated directly with a mixture of formic and acetic acid to obtain the W °-formyl derivative (FmAPA, 65% yield) [292]. Condensation of FmAPA with y-r-butyl a-methyl L-glutamate to form the diester (VIII. 155) was accomplished in 82% yield by a modified mixed anhydride procedure involving four cycles of in situ carboxyl group reactivation. Hydrolysis of the methyl ester and W -formyl group at the same time with NaOH proved impossible as a result of an unforeseen loss of the y-t-butyl ester. When the a-methyl ester was first removed under mild conditions with Ba(0H)2, however, the relatively stable V -formyl derivative (VIII.154) was isolated satisfactorily in 79% yield. Subsequent cleavage of the W -formyl group was then accomplished by carefully controlled hydrolysis in 0.25 M NaOH (1.75 h at 25 °C). In an alternative synthesis, FmAPA was activated by reaction with bis(4-nitrophenyl) carbonate to obtain the corresponding... 

Butyl/>-aminobenzoate Benzoic acid, 4-amino-, butyl ester U.S.P., N.F. XIII Butesin (Abbott). 

Definition Ester of n-butyl alcohol and p-aminobenzoic acid Empirical C11H15NO2 Formula H2NC6H4COOC4H9 Properties Wh. to yel. cryst. powd. sol. in 95% ethanol, chloroform, dil. acids, fatty oils, ether, benzene insol. in water m.w. 193.27 m.p. 57-58 C b.p. 173-174 C (8 mm)... 

Perfumes, Flavors, Cosmetics, and Soap. Many naturally occurring esters in essential oils and some synthetic esters are important fragrance and flavor compounds (61,62). They are used in perfumes, flavors, cosmetics, soaps, detergents, and air fresheners. Benzyl, butyl, ethyl, methyl, and phenyl esters of benzoic acid are used as flavors, perfumes, and food preservatives. Glyceryl 4-aminobenzoate [136-44-7] and 2-ethyUiexyl 4-dimethylaminobenzoate [21245-02-3] are used in cosmetic sunscreen preparations. Alkyl esters of 4-hydroxybenzoic acid, called parabens, have been used under various names for fungus infections of the skin, and as preservatives in lotions and creams (101). Soap and cosmetic fragrances use large amounts of amyl and benzyl saHcylate. Benzyl saHcylate [118-58-1] is also used in deodorant sprays. 2-Ethylhexyl saHcylate [118-60-5] and 2-ethylhexyl 4-methoxycinnamate [5466-77-3] are used in sunscreen formulations (102). 

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