Aminobenzoic Acid as Growth Factor

This has been examined using Acetobacter suhoxydans and Cl. acetobulyl-icum, and the results (Table XVIII) for these organisms are in substantial agreement. There are some discrepancies in the observations recorded for Cl. acetobutylicum with a few of the compounds. Rubbo and Gillespie (324) reported that p-aminophenylacetic acid was 10 times more active than p-aminobenzoic acid, but other observers have failed to confirm this (183, 456). Lampen and Peterson (183) found that the apparent activity of commercial p-aminophenylacetic acid fell from 0.1% of the potency of p-aminobenzoic acid to 0.002%, after two recrystallizations. Rubbo and Gillespie (324) and Landy and Wyeno (197) noted that p-aminophenylace- 

Specificity of p-Aminohenzoic Acid as Bacterial Growth Factor 

Compound Organism Acetsiceter Cl. oulobutyliam suinyians, . . Sefereoces (192) (183) (324)  

Bacteriostatic Effects of Compounds Related to p-Aminobemoic Acid (142) 

Compound Minimuih concentration (/ig./ml.) Max. for bacteriostatic effect over cone. 64 hr. period tested E. colt 6. hemolyiiats D. pneumonUc  

---

Numerous species of bacteria which do not require p-aminobenzoic acid as growth factor are inhibited by sulfanilyl compounds, the inhibition being reversed by p-aminobenzoic acid, e.g., meningococci (385) Esch. coli (149) Diplococcus pneumoniae (197) Staph, aureus (197). In the two latter cases the specificity of p-aminobenzoic acid was examined the o- and m-compounds were not active in abolishing the inhibition. 

---