Amino precursor

Side-chain bromination occurred when 5,6-dimethyl-2,l,3-benzothiadi-azole was treated with NBS (87CB1593). Both the 4- and the 4,7-dihaloge-nated compounds are readily made from the diazotized amino precursors (63JGU1714). 

Levodopa is the amino precursor of dopamine. It is used to replenish depleted dopamine in Parkinson s disease. Levodopa may cause insomnia, reddish discoloration of urine and headache. 

F]-Fluoride-PET Imaging of bone metastases [ F]FET-PET Imaging with amino acids [ F]Fluorodopa-PET Imaging with amino precursors Acknowledgments References Note from the Editors... 

As far as cation complexation by crown ethers is concerned, N-(dithiocarbamato)-2-aminomethyl-15(18)-crown-5(6) ethers, obtained by reaction of the appropriate amino precursor with CS2 and alkali metal hydroxide <2006BCC473>, form highly stable cationic "mTc-nitrido complexes, which have been evaluated as radiopharmaceuticals for heart imaging <2006NMB419, 2007JCD1183>. 

Imidazo[4,5-0]quinazoline-4,9-diones (406) were synthesized as purine mimics. They were obtained from the 4-amino precursor and Fremy s salt or from the 4,9-unsubstituted derivatives with nitrogen dioxide. In strong acid, a diprotonated quinone is present (86JOC4784). 

In related work, Brimacombe s group have described two separate approaches to the synthesis of the amino-precursor of (20) starting from methyl 3-acetamido-2,3,6-trideoxy-3-C-methyl-Q -L-glucopyranoside, and have also synthesized the corresponding D-enantiomer of the precursor. ... 

The preparation of 3-fluoro-4-nitropyridine can be effected by oxidation of the aminofluoro compound with persulfuric acid. A similar reaction yields 4-nltrotetrafluoropyridine from the corresponding amino precursor. 4-Nitrotetrafluoropyridine is a liquid whose boiling point (152 to 154°) is appreciably lower than that of 2-nitropyridine (256°), or of 3-nitropyridine (216°). 

---