3-Amino-5-methyl-isoxazole

Carbethoxy-4-hydrOxy-2-methyl-2H-1 -benzothiazine-1,1-dioxide 3-Amino-5-methyl-isoxazole... 

Preparation of S-Acetylsulfanilamido-S-Methy/isoxazole 0.9 gram of 3-amino-5-methyl-isoxazole in 5 cc of pyridine was allowed to react with 2.0 grams of acetylsulfanil chloride accompanied by the generation of heat. After about one hour, water was added to the reaction mixture and the crystal precipitated out was recrystallized from alcohol to give 2.5 grams of 3-acetylsulfanilamido-5-methylisoxazole, melting point (decomposition) 220° to 221°C. 

Sulfamethoxazole 4 - Amino -N- 5 -methyl-3 - isoxazolyl)benzene sulfonamide Sulfonylation of aniline, sulfphoamidation with 3-amino-5-methyl-isoxazol... 

The differences in the chemical behavior of AI isomers are closely related to some physicochemical parameters, such as basicity and protonation site. Basicity of 4-AI is higher than that of 3-AI or 5-AI (Table 1), and there is a significant difference in the site of protonation. In 75% H2S04, 4-amino-3,5-dimethylisoxazole is ca. 50% diprotonated. The diprotonation of 3-amino-5-methyl isoxazole starts in 75% H2S04, while the diprotonation of 5-amino-3-methylisoxazole does not begin (89JCS(P2)1941). All the AI isomers are only monoprotonated in trifluoroacetic... 

Seizure maintenance is largely caused by glutamate acting on postsynap-tic N-methyl-D-aspartate and a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/akinate receptors. Sustained depolarization can result in neuronal death. 

NMDA, Af-methyl-D-aspartate AMPA, a-amino-3-hydroxy-5-methyl-isoxazole-4-proprionic add 1S,3R-ACPD, L-amino-cydopentane-lS,3R-dicarboxylic add IP3, inosine triphosphate... 

Stanley, B. G., L. H. Ha, L. C. Spears and M. G. Dee, 2nd (1993). Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res 613(1) 88-95. 

Giberti, A., Ratti, E., Gaviraghi, G., van Amsterdam, F.Th.M., 1991. Binding of DL-[ H]-a-amino-3-hydroxy-5-methyl-isoxazole-4-pro-pionic acid (AMPA) to rat cortex membranes reveals two sites or affinity states. J. Recept. Res. 11 (5), 727-741. 

Methyl-isoxazole-(3)-carboxylic acid chloride 4-( 3-Aminoethyl)benzene sulfonamide hydrochloride Chloroformic acid methyl ester N-Amino-hexamethylene imine... 

Although isoxazoles are comparatively weak electron donors, complexes with numerous metal ions, notable metal(II) ions, have been reported. The ligands include isoxazole and its methyl, phenyl, amino and hydroxy derivatives. They are listed with references in Table 5. 

Isocyanide, benzyl, 55, 98 Isocyanide, butyl-, 55, 98 Isocyanide, cyclohexyl-, 55, 98 ISOCYANIDE, 1,1-dimethylethyl- [Isocy-amde, tert-butyl-], 55,96 Isocyanide, dodecanyl- 55,98 Isocyanide, ethyl- 55,98 Isocyanide, methyl-, 55, 98 Isocyanide, phenyl-, 55, 98 1//Isoindole 1,3(2//) dione, 2 amino [Phthahmidc, N-amino-], 55, 115 1//-ISOINDOLE-1,3(2//)-DIONE, trans-( )-2-(2,3-diphenyl-l-aziridinvl)-[Azindine, frans-2,3-diphenyl-l-phthalimido-], 55, 115 ISOXAZOLE, 3-(4-chlorophenyl)-5-(4-methoxy phenyl)-, 55, 39 Isoxazole 5-(4-chlorophenyl)-3-(4-meth-oxyphenyl)-, 55, 42... 

Nofe. AMPA = amino-3-hydroxy-5--methyl-4-isoxazole propionate GABA=y-aminobutyric acid. 

AMPAR. (a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system. 

Non-NMDA ionotropic glutamate receptors (the majority sodium channel containing) can be subdivided into a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) (comprising cloned subunits GluRl ) and kainate (GluR5-7, KAl-2) preferring receptors, with native receptors most likely to comprise either homo- or heteromeric pentamers of these subunits. 

Abbreviations N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), L(+)-2 amino-3-phosphonopropionic acid (L-AP3), 6-cyano-7-nitroqninoxaline (CNQ5Q, 2,3-dihydroxy-6-nitro-7-sulfamyl-benzo-f-quinoxaline (NBQX), 3-(2-carboxypiperazin-4-yl)-propyl-l-phosphonic acid (CPP), 7 Chlorokynnreic... 

AMPA a-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid... 

A one-pot synthesis of 3-methyl-5-aryl-4//-pyrrolo[2,3-<7]isoxazoles was performed in high yields by Sharpless epoxidation of 4-amino-3-methyl-5-styrylisoxazoles <06TL4957>. 1,2,4,5-Tetrazines were condensed with isoxazolylcyclobutanones in methanolic KOH to give conformationally restricted 6-isoxazol-5-yl-6,7-dihydro-5//-[l,2]diazocin-4-ones <06JOC2480>. 

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