4-Amino-5-imidazolecarboxamide ribotide

F2. Flaks, J. G., Erwin, M. J., and Buchaium, J. M., Biosynthesis of the purines— the synthesis of adenosine 5 phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase. J. Biol. Chem. 288, 201 (1957). 

It is of interest that many of the reduced folic derivatives prepared as a result of chemical studies of growth factors have subsequently been foimd to serve directly as coenzymes in the transfer of single carbon units. Reversible enzymatic transfer of the single carbon unit from anhydrofolinic acid to glycineamide ribotide, from Ai -formyltetrahydrofolic acid to 5-amino-4-imidazolecarboxamide ribotide, and from folinic acid to glutamic acid have been observed to be specific for these respective formyl donors -. ... 

AICAR, 5-d mitio-1-(S-O-phosphono-0-i>-ribo-juranosyil-IH-imidazole-4-carboxamide S-amino-l-ribo-juranosylimidazoie-4-carboxamide S -phosphate 5-amino -4-imidazo]ecarboxamide ribonucleotide 5-amino -4-imid-azolecarboxamide ribotide 5-amino-I-<5 -phosphofurano-ribosyl)-4-imidazolecarboxamide. C,H SN40,P mol wt 338.22. C 31.96%, H 4.47%, N 16.57%. O 37.85%, P 9.16%. Synthesis from AIR Lukens, Buchanan, J. Am. Chem. Soc. 79, [511 (1957) J. Biol. Chem. 234, 1791 (1959). 

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