Amino functional group, 787 table

Atoms of other elements, typically oxygen, nitrogen and sulphur, are incorporated into the basic hydrocarbon structures, usually as peripheral components known as functional groups (Table 2.1). Each functional group confers specific properties on the compound, and can be a major factor in determining the chemical behaviour of the compound. Functional groups include the hydroxyl (-OH), carboxyl (-COOH), amino (-NH2) and nitro groups (-N02). The -OH and... 

Aminolysis of chloropteridines has been used extensively for the introduction of specific amino functional groups into the pteridinc system (see Table 18). The rates of reaction of simple chloropteridines have not been measured and compared, but from a variety of data it seems likely that the order of reactivity of the n-chloropteridines is 7 > 6 > 4 > 2. 

Refer to the structure of procaine in the table in the essay "Local Anesthetics." Using p-amin-obenzoic acid, give equations showing how procaine and procaine monohydrochloride could be prepared. Which of the two possible amino functional groups in procaine will be proto-nated first Defend your choice. Hint Consider resonance.)... 

In the simplest case, R=H (aminoacetic acid or glycine). In other amino acids, R is an aliphatic, aromatic or heterocyclic residue and may incorporate other functional groups. Table 1.1 shows the most important building blocks of proteins. There are about 200 amino acids found in nature (Fig. 1.1). Some of the more uncommon ones, which occur mostly in plants in free form, are covered in Chap. 17 on vegetables. 

The UNIquac Functional group Activity Coefficient (UNIFAC) model modified by Larsen et al. [LAR 87] does not take into account the sulfur groups among the common amino acids, methionine and cysteine cannot be decomposed into functional groups (Table 3.3). 

In reality all carbon atoms share equally the pool of electrons which constitute the double bonds and benzene resists addition across the double bonds which would otherwise destroy its unique structure and stability. Single or multiple hydrogen atoms can be substituted to form a host of derivatives containing similar functional groups to those above, e.g. saturated and unsaturated aliphatic chains, amino, carboxylic acidic, halogeno, nitro, and sulphonic acid groups as shown in Table 3.6. 

The first general method, RIMP, is by far the most widely employed. As shown in Table 2 CFPs employed as catalytic supports usually possess functional groups suited for ion exchange (-SO3H or -S03Na, -COOH or -COONa, -NR3X) or metal coordination (amino, cyano, pyridyl,... 

The alkoxycarbonyl protecting groups can also be introduced into amines by, triazolides (Table 4—7). With A-tert-butoxycarbonyl-1,2,4-triazole the tert-butoxy-carbonyl protecting group (Boc) is transferred readily onto amino functions of primary amines, trimethylbenzyl ammonium salts of amino acids, or peptides.[ 1965 Alternatively, the Boc group can be transferred with terf-butylphenylcarbonate in the presence of 1,2,4-triazole. In this latter approach the triazolide is presumably formed as an intermediate. ... 

A comparison of the relative strength of functional groups to cause a-cleavage is summarized in Table 6.5. [6] This also corresponds to a rough measure of relative charge-stabilizing capability of the respective substituent, e.g., the ratio H2C=0H /H2C=NH2 from 2-amino ethanol molecular ion is 2.3/100 and the ratio of H2C=0H /H2C=SH from 2-thio ethanol molecular ion is 42/70. [20]... 

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