2-Amino-4-fluorobenzoic acid

Potassium carbonate 2-Amino-4-fluorobenzoic acid Sodium hydride Triethyl orthoformate... 

A solution of 2-amino-4-fluorobenzoic acid (62 g) in aqueous sodium carbonate (44 g sodium carbonate in 1.6 liters water) was stirred and treated dropwise with a solution of phosgene (120 g) in toluene (500 ml) during 1.5 hours. The resulting suspension was stirred at room temperature for 24 hours. The solid product was collected by filtration, washed with water and dried to give 7-fluoro-l,2-dihydro-3,l(4H)-benzoxazine-2,4-dione melting point 217-219°C. 

Amino-4-fluorobenzoic acid (5.41 mmol) dissolved in 15 ml ethyl alcohol was treated with 1.18 ml thionyl chloride, then refluxed overnight, and concentrated. The residue was dissolved in EtOAc, washed with 10% NaOH solution then dried, concentrated, and the product isolated in 82% as a solid. 

C7H6BrN02 2-bromo-1 -methyl-4-nitrobenzene 7745-93-9 r 25.00 1,6545 2 10299 C7H6FN02 2-amino-4-fluorobenzoic acid 446-32-2 25.20 1.3021 2... 

Amino-3-fluorobenzoic acid, A-70140 2-Amino-4-fluorobenzoic acid, A-70141 2-Amino-5-fluorobenzoic acid, A-70142... 

AMINO-3-FLUOROBENZOIC ACID [Benzoic acid, 2-amino-3-fluoro-]... 

Amino-3-fluorobenzoic acid is an important intermediate in the synthesis of derivatives of indole, such as the potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist L-670,596 or the anti-inflammatory agent Etodolac. Compounds of this type have therapeutic applications. 2-Amino-3-fluoro-benzoic add is aiso an important precursor for the synthesis of fluoroacridines, which can be converted to interesting tridentate ligands, such as Acriphos. ... 

Amino-3-fluorobenzoic acid Anthranilic acid, 3-fluoro- (8) Benzoic acid, 2-amino-3-fluoro-(10) (825-22-9)... 

A/-[4-[(4-[ F]Fluorobenzylidene)amino-oxy]butyl]maleimide ([ F]FBABM) was synthesised in two steps, involving the preparation of 4-[ F]fluorobenzaldehyde (see Section 4.3.1.1), in an overall radiochemical yield of 35% in 60 min [267], whereas A/-[2-(4-[ F]fluorobenzamido)ethyl]maleimide ([ F]FBEM) was synthesised in three steps via 4-[ F]fluorobenzoic acid (see Section 4.3.1.1) in an overall radiochemical yield of 12% in 150 min [268]. Finally, based on the successful use of nucleophilic /leferoaromatic ort/io-radiofluorination in the pyridine series (see Section 4.3.2.1), 1-[3-(2-p F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione was prepared in 17-20% non-decay-corrected radiochemical yield in a three-step pathway taking less than 110 min [13,269]. These three reagents have been successfully coupled to peptides and proteins (>80% radiochemical yield in 10 min). 

C7H6Br2 3-bromobenzyl bromide 823-78-9 515.15 45.342 2 10297 C7H6FN02 2-amino-6-fluorobenzoic acid 434-76-4 496.82 43.578 2... 

C7H5FO2 4-Fluorobenzoic acid 25 4.15 C7H7N03 4-Amino-2-hydroxy- 3.25... 

Dichloro-5-fluorobenzoic acid or 2,4,6-trifluorobromobenzene have been the starting materials to have access to C-8 nitro, amino, cyano, or trifluoromethyl derivatives [24, 25, 29, 30] (Fig. 14). 

Hydroxyl groups can be introduced by the treatment with sodium borohydride [21], The hydroxyl groups (PEEK-OH) can be further reacted with 4-amino-benzoic acid or succinamic acid to give carboxyl-modified PEEK surfaces. Moreover, PEEK can be aminated [22]. Functionalized arylazides can be readily grafted on the PEEK film surfaces by UV irradiation [23]. Aromatic azides, such as 4-azido-tetra-fluorobenzoic acid, or A-butyl-A -(4-azidophenyl)-thiourea, belong to the class of photoactivatable reagents. These compounds can be photo-grafted onto PEEK. 

A mixture of formamide (7, 5.4 g, 120 mmol) and 2-amino-5-fluorobenzoic acid (49, 2.4 g, 15 mmol) was heated with stirring at 135 °C for 7 h. The mixture was then poured into ice water (10 mL). The crude product was collected by filtration and recrystallized from ethanol to afford 50 (2.46 g, 53% yield) mp 258-261 °C. 

Amino-2-fluorobenzoic acid, A-70145 > 4-Amino-3-fluorobenzoic acid, A-70146... 

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