4- Amino-5-ethoxycarbonyl-2-methyl

Amino- -(ethoxycarbonyl-methyl-atnid) XV/1, 99, 283 -(1, l-dimethyl-2 nitro-ethylamid) E5, 1040... 

Thiazole, 5-amino-4-ethoxycarbonyl-2-methyl-synthesis, 6, 306 Thiazole, 2-amino-4-(2 -furyl)-bromination, 6, 256 Thiazole, 2-amino-4-hydroxy-synthesis, 6, 296 Thiazole, 5-amino-2-hydroxy-synthesis, 6, 301 Thiazole, 5-amino-2-mercapto-synthesis, 6, 301 Thiazole, 2-amino-4-methyl-alkylation, 6, 256 synthesis, 6, 300 Thiazole, 2-amino-5-nitro-antiparasitic activity, 1, 180... 

Thiophene, 2-amino-3-cyano-5-phenyl-synthesis, 4, 888-889 Thiophene, 3-amino-4,5-dihydro-cycloaddition reactions, 4, 848 Thiophene, 2-amino-3-ethoxycarbonyl-ring opening, 4, 73 Thiophene, 2-amino-5-methyl-synthesis, 4, 73 Thiophene, 2-anilino-synthesis, 4, 923-924 Thiophene, aryl-synthesis, 4, 836, 914-916 Thiophene, 2-(arylamino)-3-nitro-synthesis, 4, 892 Thiophene, azido-nitrenes, 4, 818-820 reactions, 4, 818-820 thermal fragmentation, 4, 819-820 Thiophene, 3-azido-4-formyl-reactions... 

Cyclization of methyl 2-[2-benzoyl-2-ethoxycarbonyl-l-vinyl)amino]-3-[(4-methyl-2-pyridyl)amino]acrylate (311) afforded the 3-amino-8-methyl-4//-pyrido[l,2-n]pyrimidin-4-one derivative 312 (97JHC1511). 

Two other results should be reviewed here, too. The substituted thiadiazolo[3,2-trifluoromethyl groups) was described by Sokolov and Aksinenko <2003IZV2053> 2-amino-5-methyl[l,3,4]thiadiazole 165 was heated with iV-ethoxycarbonyl-bis-trifluoroacetone imine in DMF in the presence of />-toluenesulfonic acid to yield the cyclized product 166 in good yield (77%). 

Modifications of the guanidino function of Zanamivir (1) at the primary nitrogen resulted in a dramatic reduction in the inhibition of NA and of viral replication in vivo. 7V3-Nitro, ethoxycarbonyl, methyl, hydroxy, and amino derivatives 28-32 inhibited the catalytic action of NA between 300 and 3000 times... 

H-Purin 2-Amino-6-sulfino-(Na-Salz) IV/la, 161 1,2,3,4-Thiatriazol 5-(Diazo-ethoxycarbonyl-methyl)- E8d,... 

Acrylsaure tnms -3-(Ethoxycarbonyl-methyl-amino)-2-lithio- -methylester E19d, 186 (H -> Li)... 

Pyrazol 4-Ethoxycarbonyl-5-(ethoxymethylen-amino)-l -methyl- E16a, 741 (Imin-Bild.)... 

Pyrido 2,3-b pyrazin 8-Amino-6-(ethoxycarbonyl-amino)-2-methyl- E9c, 237 ( — H2 - Hetaren)... 

Pyrrol 5-Amino-4-cyan-2,3-dimethyl-1 -(ethoxycarbonyl-methyl)- E6a, 638 [H3C-CO-CH(CH3)-OH + H2N-CH2-COOR ... 

Benzothiophen 2-Amino-3-ethoxycarbonyl-6-methyl- E6a, 225 (Cyclohexanon + NC-CH2-COOR/S8) Butansaure 2-Amino-3-benzylthio-3-methyl- Xl/2, 453 4H-[Pg.1044]

Butensanre 3-(4-Methoxy-ani-lino)- -ethylester VIII, 627 Chroman 4-(Ethoxycarbonyl-amino)-2-methyl- V/lc, 1106 Cyciobutan 2-(2,5-Dimethoxy-4-methyl-phenyl)-l -hydroximino-E17e, 421 (Oxo - Oxim) Cyclohexan tronj-2-Methoxy-l-(2-nitro-phenylthio)- E21e, 5033 (En -> OR/SAr)... 

S,.S)-2-(l-(Benzyloxycarbonyl-amino)-2-methyl-butyl]-4-ethoxycarbonyl-l,3-thiazollq2 ... 

C2H5 Br —CH, — COOC2H5 Aceton 20 1 2-Amino-3- ( ethoxycarbonyl-methyl) -5- 78 141-143 1056... 

Amino-2-methyl-5-pyrimidin-yl-methyl)-2-(l-ethoxycarbonyl- 1-hydroxy-ethyl) -5- (2-hydr-oxy-e.thyl)-4-methyl-l, 3-thiazoliumchlorid Hydrochloride 85% Schmp. 224-226°... 

Aus (Ethoxy-methylen)-malonsaure-ethylester-nitril und -dinitril entstehen mit Hydrazino-es-sigsaure-ethylester in Gegenwart von Natriumcarbonat 3-Amino-4-ethoxycarbonyl-l-(ethoxy-carbonyl-methyl)- (50% Schmp. 162°) bzw. 3-Amino-4-cyan-l-(ethoxycarbonyl-methyl)-lH-pyrazol (50% Schmp. 101°)530. 

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