2-amino-3,4-dimethylimidazo 4,5-/ quinoline MelQ

As in the case of the carcinogens whose activity can be substantially reduced by anticarcinogens [see review by Rodgman (3255)], Lee et al. (2327c) reported that mainstream CSC significantly inhibited the mutagenicity of several of these A-heterocyclic amines when tested in the Ames assay with Salmonella typhimurium, strain TA 98 in the presence of the S-9 mix. The A-heterocyclic amines tested included 2-amino-3-methylimidazo[4,5-/]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-/]quinoline (MelQ), 2-amino-6-methyl-dipyrido[l,2-fl 3 ,2 - /]imidazole(Glu-P-l), 2-aminodipyrido[l,2-fl 3 ,2 - /]imidazole (Glu-P-2), 3-amino-... 

Kinae et al. (2095a) reported that A-heterocyclic amines [2-amino-3-methylimidazo[4,5-/ quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-/ quinoline (MelQ), l-methyl-6-phenyl-l//-imidazo[4,5-/7]pyridin-2-amine (PhIP)] were produced in an incubated solution of D-glucose and several amino acids at much lower temperatures and longer time periods than those encountered in the cooking of various foodstuffs (beef, poultry, fish). Several A-heterocyclic amines not found in CSC were also generated. The generation of the A-heterocyclic amines, as measured by the Ames test (Salmonella typhimurium TA 98), increased in proportion to the conditions imposed 37°C (90 d), 50°C (30 d), 128°C (2 h)... 

PHAs identified in cooked foods that are of concern to human health include 2-amino-3-methylimidazo[4,5-/Iquinoline (IQ), 2-amino-3,4-dimethyl-3H-imidazo[4,5-/ quinoline (MelQ), 2-amino-3,8-dimethylimidazo[4,5-/Iquinoxaline (MelQx), 2-amino-2,4,8 (or 3,7,8)-trimethylimidazo[4,5-/Iquinoxaline (diMelQx), 2-amino-iV-methyl-5-phenylimidazopyridine (PhIP), 3-amino-l,4-dimethyl-5/f-pyrido[4,3-fe]indole (Trp-P-1), 3-amino-l-methyl-5H-... 

Ohgaki H., Hasegawa H., Suenaga M., Sato S., Takayama S. and Sugimura T. Induction of tumors in the forestomach and liver of mice by feeding 2-amino-3,4-dimethylimidazo[4,5-f] quinoline (MelQ). Proceedings of the Japanese Academy of Sciences. 61,137. 1985. 

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