2-Amino-4,6-dichloro-1,3,5-triazine

Kay G, Lilly MD. The chemical attachment of chymotrypsin to water-insoluble polymers using 2-amino-4,6-dichloro- -triazine. Biochim. Biophys. Acta 1970 198 276-285. 

Hexanediamine, N,N -bis (2,2,6,6-tetramethyl-4-piperidinyl)-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction prods, with N-butyl-1-butanamine and N-butyl-2,2,6,6-tetramethyl-4-piperidinamine stabilizer, light food-grade polymers Benzophenone-12 N,N -Bis (2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine polymer with 2,4-dichloro-6-(4-morpholinyl)-1,3,5,-triazine 3,5-Di-t-butyl-4-hydroxybenzoic acid, n-hexadecyl ester Drometrizole Poly [f6-[(1,1,3,3-tetramethylbutyl) amino]-s-triazine-2,4-diyl] [(2,2,6,6-tetramethyl-4-piperidyl) imino] hexamethylene [(2,2,6,6-tetramethyl-4-piperidyl) imino]] stabilizer, light garden... 

Series 2-amino-4-anilino-6-chloro- -triazine k in liter xmole i x sec i. Ref. 49. Series 2-substituted-4,6-dichloro- -triazine k in hr i. Ref. 39. 

In connection with the biological activity of s-triazines, Burchfield and Storrs investigated the reaction of 2,4-dichloro-6-(o-chloro-anilino)-s-triazine with over sixty amino acids, peptides, and related... 

Series 2-amino-4,6-dichloro-s-triazine k in liter x mole i x min i. Ref. 27. 

Sodium methyl mercaptide in xylene was reported to react (25°, 2 hr) in a stepwise fashion with 3,5-dichloro-as-triazine to yield the 3-methylthio-5-chloro and then (70°, 2 hr) the 3,5-bis-methylthio derivatives. However, the structure of the former is very likely to be 307. With dimethylamine in benzene (25°, 5 min), ethyleneimine in ether (25°, 3 min), and alcoholic ammonia (25°, few min), this dichloro derivative was assumed to form 3-amino derivatives. The high reactivity of as-triazines is demonstrated by the facile ethoxylation... 

A relatively uncontrolled attempt to enhance the colour yield and fastness to washing of selected direct dyes involved addition to the dyebath of a colourless reactant that was intended to form covalent attachments between these dyes and hydroxy groups in cellulose [135]. Most of the dyes selected contained at least two primary amino groups in aminonaphthol residues. The reactants evaluated were cyanuric chloride (7.3), N,N-diethyl-3-hydroxyazetidinium chloride (7.124) and 2,4-dichloro-6-(4,-sulphoanilino)-s-triazine (7.125), all of which will indeed react readily with primary arylamines. Some of the dyes selected, however, contained only diphenylurea or salicylic acid residues and these are most unlikely to react efficiently under dyeing conditions. 

The more nitrogen the heteroaromatic nucleus contains, the more easily reducible it is in such cases the nucleus may be reduced in preference to a carbon-halogen bond. Thus whereas the first reduction of 2-(diethyl-amino)-4,6-dichloro-s-triazine in aqueous solution is a reductive removal of a chlorine, the second reduction is of the nucleus.437,438... 

The presence of substituents which can conjugate with the triazine ring produces the expected bathochromic shift and the band may be very intense for example, the 4,6-dichloro-2-(4-nitrophenyl) derivative shows an intense band (e = 24 700) at 279 nm (61RTC158). Mono- and di-amino-1,3,5-triazines show a significant band at ca. 260 nm 2-amino-l,3,5-triazine absorbs at 261 nm (e = 1960). 

The 2-alkyl and 2-aryl derivatives are best prepared by the reaction between 1,3,5-triazine and an imidate or amidine (see Section 2.20.3.1.2). 2-Amino-l,3,5-triazines may be prepared efficiently by (a) treatment of 1,3,5-triazine with 1-amidinopyrazole (see Section 2.20.3.1) (b) condensation of triformidomethane and a formylguanidine (see Section 2.20.4.3.3). 2-Aryloxy derivatives are produced by hydrogenation of the corresponding dichloro-l,3,5-triazine derivative (see Section 2.20.3.12). 

Madelmont and Veyre have reported the preparation of (206) from cyanuric chloride (75MI22002). The compound is valuable in the dynamic exploration of the lymphatic system, when it is prepared using radioactive isotopes of iodine. 2,4-Dichloro-l,3,5-triazines containing a secondary amino group with a vinylic substituent have promise in binding dental resins to biological tissues. The chlorines react with the dentine tooth enamel whilst the vinyl moiety bonds to the resin (75GEP2630745). 

With dimethylamine in benzene (25°, 5 min), ethyleneimine in ether (25°, 3 min), and alcoholic ammonia (25°, few min), this dichloro derivative was assumed to form 3-amino derivatives. The high reactivity of os-triazines is demonstrated by the facile ethoxylation... 

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