Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Amino acids, halogenated

Has been used for a wide variety of compounds, including amino acids, halogenated organics, explosives... [Pg.108]

Ion mobility detector (IMD) 1 X 10- g 1 X 10 to 1 X 10 10 Amenable to use in handheld instruments Linear dynamic range of 10 for radioactive sources and 10 for photo-ionization sources Selectivity depends on mobility differences of ions Has been used for a wide variety of compounds including amino acids, halogenated organics, explosives The radioactive Ni source is subject to regulation and periodic inspection... [Pg.1433]

Eig. 3. Stmctures of the thyroidal iodinated amino acids and the halogen-free analogue DlMlT (3). Compound (4) is reverse-T. ... [Pg.47]

Caprolactam is an amide and, therefore, undergoes the reactions of this class of compounds. It can be hydrolyzed, Ai-alkylated, O-alkylated, nitrosated, halogenated, and subjected to many other reactions (3). Caprolactam is readily converted to high molecular weight, linear nylon-6 polymers. Through a complex series of reactions, caprolactam can be converted to the biologically and nutritionally essential amino acid L-lysine (10) (see Amino acids). [Pg.428]

Amino Acids. The formation of A/-halo-a-amino acids involves halogenation of the acid anion (13). /V-Cb1oro-CX-amino acids decompose to aldehydes and nitriles, the selectivity depending on pH and stoichiometry (110). For example, AJ-chloroalanine decomposes in the 6.5—10 pH range. [Pg.456]

After the complete removal of halogen and metallic ions, the solution is concentrated to a volume of about 100 cc., and 300 cc. of absolute alcohol is added. Then the amino acid is precipitated by slowly adding 500 cc. of ether with stirring and cooling. [Pg.7]

Nucleophilic substitution by ammonia on a-halo acids (Section 19.16) The a-halo acids obtained by halogenation of carboxylic acids under conditions of the Hell-Volhard-Zelinsky reaction are reactive substrates in nucleophilic substitution processes. A standard method for the preparation of a-amino acids is displacement of halide from a-halo acids by nucleophilic substitution using excess aqueous ammonia. [Pg.928]

The activity of PK and NRPSs is often precluded and/or followed by actions upon the natural products by modifying enzymes. There exists a first level of diversity in which the monomers for respective synthases must be created. For instance, in the case of many NRPs, noncanonical amino acids must be biosynthesized by a series of enzymes found within the biosynthetic gene cluster in order for the peptides to be available for elongation by the NRPS. A second level of molecular diversity comes into play via post-synthase modification. Examples of these activities include macrocyclization, heterocyclization, aromatization, methylation, oxidation, reduction, halogenation, and glycosylation. Finally, a third level of diversity can occur in which molecules from disparate secondary metabolic pathways may interact, such as the modification of a natural product by an isoprenoid oligomer. Here, we will cover only a small subsection of... [Pg.299]

Much was unknown for the halogenation for unreactive substrates until very recently, when the biosynthesis of the cyclopropyl amino acid side chain of coronatine was elucidated. This intriguing pathway, which involves /-chlorination of an enzyme-bound L-isoleucine followed by chloride displacement by the a-carbon, yields the cyclopropanated precursor... [Pg.303]

Before going on to describe the functions of the metals we observe that among heavier non-metals only selenium, chlorine and other halogens need any further comment. Selenium is found in some hydrogenases in even the most primitive life forms and may be it was required initially since it is a more effective catalytic centre than sulfur although much less available. (Compare tungsten with molybdenum later.) Its amino acid selenomethionine is coded in early DNA Later it is involved... [Pg.170]

Burk et al. showed the enantioselective hydrogenation of a broad range of N-acylhydrazones 146 to occur readily with [Et-DuPhos Rh(COD)]OTf [14]. The reaction was found to be extremely chemoselective, with little or no reduction of alkenes, alkynes, ketones, aldehydes, esters, nitriles, imines, carbon-halogen, or nitro groups occurring. Excellent enantioselectivities were achieved (88-97% ee) at reasonable rates (TOF up to 500 h ) under very mild conditions (4 bar H2, 20°C). The products from these reactions could be easily converted into chiral amines or a-amino acids by cleavage of the N-N bond with samarium diiodide. [Pg.822]


See other pages where Amino acids, halogenated is mentioned: [Pg.50]    [Pg.50]    [Pg.249]    [Pg.38]    [Pg.321]    [Pg.502]    [Pg.1]    [Pg.267]    [Pg.456]    [Pg.23]    [Pg.18]    [Pg.105]    [Pg.551]    [Pg.89]    [Pg.350]    [Pg.82]    [Pg.1549]    [Pg.375]    [Pg.63]    [Pg.360]    [Pg.470]    [Pg.373]    [Pg.374]    [Pg.786]    [Pg.728]    [Pg.310]    [Pg.7]    [Pg.5]    [Pg.190]    [Pg.411]    [Pg.128]    [Pg.55]    [Pg.794]    [Pg.665]    [Pg.292]    [Pg.13]    [Pg.91]   
See also in sourсe #XX -- [ Pg.134 ]




SEARCH



Acids, halogenation

Halogenated acids

© 2024 chempedia.info