Amino acids arylation with phenylboronic

Early examples of the total synthesis of naturally occurring indole alkaloids employing the Suzuki reaction include ellipticine (10) as repotted by Miller et al. [34], The aryl bromide, 6-amino-7-bromo-5,8-dimethylisoquinoline (45) was derived from 2,5-dimethylanilinc in nine steps. The Suzuki coupling of 45 with phenylboronic acid was carried out using catalytic tetrakis(triphenylphosphine)palladium in benzene and with Na,CO, serving as the base to furnish... 

Acyclic aminocarbenes have not been used widely as ligands for transition metal catalysts. The amino(aryl)carbene complexes 26 and 27 are rare examples that showed moderate activity in the Suzuki coupling of aryl iodides and bromides with phenylboronic acid (Figure 5.7). ... 

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