Amines aza macrocycles from

X-ray photoelectron spectroscopy, 139 Diazo ligands, 100 Dicarbonyl compounds reaction with amines aza macrocycles from, 902... 

Triflamides can be deprotected reductively (Sodium-Ammonia) to yield the corresponding amines.This protocol has been employed in the facile two-step synthesis of aza macrocycles starting from trifluoromethanesulfonyl derivatives of linear tetramines (eq 8). ... 

Chirality derived from the readily accessible a-amino acids has been incorporated into the side chains of aza and diaza macrocyclic polyethers. A number of procedures suitable for peptide synthesis have proved (178) to be unsuitable for acylating the relatively unreactive secondary amine groups of aza crown ethers. Eventually, it was discovered that mixed anhydrides of diphenylphos-phinic acid and alkoxycarbonyl-L-alanine derivatives do yield amides, which can be reduced to the corresponding amines, e.g., l-172. By contrast, the corresponding bisamides of diaza-15-crown-S derivatives could not be reduced and so an alternative approach, involving the use of chiral A-chloroacetamido alcohols derived from a-amino acids, has been employed (178) in the synthesis of chiral receptors, such as ll-173 to ll-175, based on this constitution. 

Hexaaza- 10,22-dioxacyclotetracosane The macrocycle prepared from 2,6-diacetylpyridine and m-xylylenediamine using [Cu(p.-Im)Cu]3 + as a template 7-Amino-4-methyl-5-aza-3-hepten-2-onato Tris(2-aminoethyl)amine... 

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