Aminergic hormones

However, receptor autoradiography and in vitro studies have suggested that H3 receptors are located on other aminergic neurons in the brain. Since amines such as serotonin and catecholamines are involved in the regulation of pituitary hormone secretion, it is obvious that an action of the H3 receptor compounds may be exerted via these H3 heteroreceptors. Only few studies have evaluated this heteroreceptor action. It has been excluded that the effect of the H3 receptor agonists is due to an effect on H3 receptors located on serotonergic neurons, while an effect on catecholaminergic neurons has yet not been excluded. 

Conclusions. There is now considerable evidence that peptide hormones and catecholamines have the potential to act on acquisition, on the maintenance of learned responses, and on memory processing. The neurobiological mechanisms by which these systems act is less clear. The problem is not that central effects of the hormones and drugs are unknown but, rather, that too many effects are recognized. Therefore, it is difficult to assess which of this large set of events mediates the hormonal and aminergic... 

Aminergic GPCRs Peptide GPCRs Protein kinases Phosphodiesterases Nuclear hormone receptors ----------All literature compounds... 

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