Amine acetyl transfer between

This enzyme catalyses reactions with many aromatic amines including serotonin. It can also catalyse acetyl transfer between arylamines without CoA. 

This enzyme [EC 2.3.1.5], also known as acetyl-CoA arylamine A-acetyltransferase and arylamine acetylase, catalyzes the reaction of acetyl-CoA with an arylamine to produce coenzyme A and an A-acetylarylamine. This enzyme exhibits a low specificity with respect to the aromatic amine substrate. In fact, even serotonin can serve as a substrate. The enzyme has also been reported to catalyze acetyl-transfer reactions between arylamines without the use of coenzyme A. 

Acyl residues are usually activated by transfer to coenzyme A (2). In coenzyme A (see p. 12), pantetheine is linked to 3 -phos-pho-ADP by a phosphoric acid anhydride bond. Pantetheine consists of three components connected by amide bonds—pantoic acid, alanine, and cysteamine. The latter two components are biogenic amines formed by the decarboxylation of aspartate and cysteine, respectively. The compound formed from pantoic acid and p-alanine (pantothenic acid) has vitamin-like characteristics for humans (see p. 368). Reactions between the thiol group of the cysteamine residue and carboxylic acids give rise to thioesters, such as acetyl CoA. This reaction is strongly endergonic, and it is therefore coupled to exergonic processes. Thioesters represent the activated form of carboxylic adds, because acyl residues of this type have a high chemical potential and are easily transferred to other molecules. This property is often exploited in metabolism. 

The amination of 2-alkenylphenols occurred efficiently compared to 2-allylphenols and -naph-thols69. The mechanism involves a proton exchange equilibrium between the phenolic and amino functions and the photoinduced proton transfer (PPT) from the ammonium ion to the alkenyl group, followed by attack of the amine on the intermediate benzylic carbocation. No photoamination of O-methylated and O-acetylated phenols occurred at all. As a single example of diastereoselective amination, the amine 6 was produced from 5 with good yield and diastereoselectivity, although the configuration was not determined. 

It is not yet known whether uridine diphosphate AT-acetyl-n-glucos-amine can be formed by a transfer reaction between AT-acetyl-n-glucos-amine and uridine diphosphate D-glucose. ... 

Triphenylbismuth carbonate generally does not react with amines, although phenyl transfer to the amino functionality was first observed during an attempt of oxidation of the hydroxyl function of an aminoalcohol by triphenylbismuth carbonate in chloroform. It also reacted with iV-phenylhydro-xylamine under neutral or basic conditions to give diphenylnitroxyl and iV,iV-diphenylacetamide after reductive acetylation (29-33%). No reaction was noted between triphenylbismuth carbonate and nitrosobenzene. High-yielding -arylation was found in the reaction of amino-alcohols with triarylbismuth diacetate in methylene dichloride under reflux. 5... 

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