Amifostine

C23H3g03Si 152185-73-4) see Docetaxel trisodiuin thiophosphate dodecahydrate (H24Na30isPS 51674-17-0) see Amifostine [S-(/f 4 )]-A,A, a-tris(phenylmethyl)oxiranemcthan-amine... [Pg.2452]

Amifostine —cytoprotectant free radical scavenger -nausea and vomiting -somnolence -transient hypotension... [Pg.167]

An informative case exists in the literature of a phosphorothioic S-acid ester. Indeed, amifostine (ethyol, WR-2721, 9.63) is a phosphorothioate first... [Pg.584]

Amifostine is hydrolyzed rapidly to 2-[(3-aminopropyl)amino]ethane-thiol (9.64) at the acidic pH of the stomach, and by alkaline phosphatases in various tissues. After intravenous administration to cancer patients, the plasma half-lives were found to be in the order of minutes. This is highly relevant, since most or all pharmacological effects of amifostine can be ascribed to its thiol metabolite. [Pg.585]

Lindegaard JC, GrauC. Has the outlook improved for amifostine as a clinical radioprotector Radiother Oncol 2000 57(2) 113-118. [Pg.20]

Wadler S, Goldberg G, Fields A, et al. The potential role of amifostine in conjunction with cisplatin in the treatment of locally advanced carcinoma of the cervix. Semin Oncol 1996 23(Suppl 8) 64-68. [Pg.62]

Buntzel J, Kuttner K, Frohlich D, Glatzel M. Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer. Ann Oncol 1998 9 505-509. [Pg.125]

During treatment, other supportive measures may include chemoprotectants against xerostomia as amifostine for patients receiving radiotherapy. A phase III study completed by Brizel and colleagues demonstrated decreased xerostomia in patients receiving amifostine prior to standard daily single modality radiation therapy (p = 0.002) (92). [Pg.169]

Brizel DM, Wasserman TH, Henke M, et al. Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol, 2000 18 3339-3345. [Pg.174]

Amifostine (Elhyol) [Antineoplastic/Thiophosphate Cytoprotective] Uses Xerostomia prophylaxis during RT (head, neck, ovarian, NSCLQ -I- renal tox w/ rqjeated cisplatin Action Prodrug, dqjhosphorylated by alkaline phosphatase to active thiol metabohte Dose 910 mg/mVd 15-min IV inf 30 min prior to chemo Caution [C, +/—] CV Dz Disp Inj SE Transient X BP (>60%), NA, flushing w/ hot or cold chills, dizziness, X Ca % somnolence, sneezing Notes Does not -1- effectiveness of cyclophosphamide + cisplatin chemo Interactions T Effects W/ antih5 pertensives EMS Monitor BP for hypotension OD Severe hypotension treat w/IV fluids... [Pg.71]

Amifostine is a cytoprotective adjuvant used to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents. It is an organic thiophosphate prodrug which is dephosphorylated to the active cytoprotective thiol metabolite. The elimination half-life of the... [Pg.462]

Acetylcysteine (Aceta-dote, Mucomyst) Albuterol (Proventil, Ventolin, Volmax) Amifostine (Ethyol) Atropine (AtroPen) Atropine/Pralidoxime (DuoDote)... [Pg.33]

Hussain AE, Blakley BW, Nicolas M, Balderston J. Assessment of the protective effects of amifostine against cisplatin-induced toxicity. 7 Otolaryngol. 2003 32 294-297. [Pg.588]

Common Name Amifostine Ethiofos Fosteamine Structural Formula ... [Pg.251]

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