Docetaxel Amifostine

C23H3g03Si 152185-73-4) see Docetaxel trisodiuin thiophosphate dodecahydrate (H24Na30isPS 51674-17-0) see Amifostine [S-(/f 4 )]-A,A, a-tris(phenylmethyl)oxiranemcthan-amine... [Pg.2452]

Amifostine had no effect on docetaxel and paclitaxel pharmacokinetics, except in one study which found that amifostine extended paclitaxel plasma circulation time. Amifostine appears not to reduce the toxicity of these taxanes. [Pg.660]

Amifostine had no effect on the pharmacokinetics of docetaxel, nor did it reduce docetaxel-induced myelotoxicity. ... [Pg.660]

Freyer G, Hennebert P, Awada A, Gil T, Kerger J, Selleslags J, Brassinne C, Hccart M, de Valeriola D. Influence of amifostine on tiie toxicity and pharmacokinetics of docetaxel in metastatic breast cancer patients a pilot study. Clin Cancer Res (2002) 8, 95-102. [Pg.660]

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