Amides proteins

L. You and F. H. Arnold, Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylform-amide, Protein Eng. 1996, 9, 77-83. 

Amino-terminal amidase Amides Proteins (asparagine and glutamine residues)... 

Useful amides— proteins, the polyamide met-enkephalin, the anticancer drug Gleevec, the penicillin antibiotics, and the cephalosporin antibiotics (Section 22.6)... 

Figure 8 The effect of mild acid hydrolysis on amides in HMW DOM. Two potentially important classes of biochemicals that likely contribute to HMW DOM are (poly)-N-acetyl amino sugars (top) and proteins (bottom). Mild acid hydrolysis of (poly)-iV-acetyl amino sugars will yield free acetic acid, but will not depolymerize the polysaccharide. The generation of acetic acid will be accompanied by a shift in the N-NMR from amide to amine. In contrast, mild acid hydrolysis of proteins does not yield acetic acid, but may depolymerize the protein macromolecular segments to yield free amino acids. Free amino acids can be quantified by chromatographic techniques and compared to the shift from amide (protein) to amine (free amino acid) in N-NMR.

Wagner, G., Wtithrich, K. (1982) Amide protein exchange and surface conformation of the basic pancreatic trypsin inhibitor in solution. Studies with two-dimensional nuclear magnetic resonance. J Mol Biol, 160 (2), 343-361. 

Acetyl (Protein M-term) Amidated (C-tenn) Amidated (Protein C-term) Ammonia-loss (N-term C) Biotin (K)... 

N-H amide as (.CONH. ) and (.CONHj) N-H (38) and N-H stretching combination Amides/proteins... 

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