Amidation nitrogen-containing

Given a nitrogen containing organic compound such as an amide a nitnle or a nitro compound how is the correct oxidation state of the desired amine to be achieved" ... 

Amide (Sections 4 1 and 20 1) Compound of the type RCNR2 Amine (Chapter 22) Molecule in which a nitrogen containing group of the type —NH2 —NHR or —NR2 is attached to an alkyl or aryl group... 

Although acetonitrile is one of the more stable nitriles, it undergoes typical nitrile reactions and is used to produce many types of nitrogen-containing compounds, eg, amides (15), amines (16,17) higher molecular weight mono- and dinitriles (18,19) halogenated nitriles (20) ketones (21) isocyanates (22) heterocycles, eg, pyridines (23), and imidazolines (24). It can be trimerized to. f-trimethyltriazine (25) and has been telomerized with ethylene (26) and copolymerized with a-epoxides (27). 

Urea (24), amino acids (25), and creatinine (26) are also decomposed during superchlorination or shock treatment, with formation of N2 and other oxidation products. However, the process is slower than with ammonium ion (see Chloramines and BROMAMINEs). Urea is the principal nitrogen-containing compound in swimming pools. Since it is an amide, it reacts slowly with chlorine, yielding N2, NCl, and NO/ (27). 

An investigation of acylaziridines was carried out by comparison of IR, NMR and MS data and included some 1,2-dibenzoylaziridines as well as 2-p-nitrobenzoyl-3-phenyl-oxaziridine (68IZV1530). Amide conjugation in acylated nitrogen-containing three-membered rings is weaker than in open chain acid amides. 

Actinide complexes with chelating ligands containing sulfur and amidic nitrogen donor atoms. U. Casellato, M. Vidali and P. A. Vigato, Coord. Chem. Rev., 1979, 28, 231-277 (181). 

Gresh, N., A. Pullman, and P. Claverie. 1985. Theoretical Studies of Molecular Conformation. II Application of the SIBFA Procedure to Molecules Containing Carbonyl and Carboxylate Oxygens and Amide Nitrogens. Theoret. Chim. Acta (Berl.) 67, 11-32. 

S Akabori, S Sakakibara, Y Shimonishi. Protection of amide nitrogen for peptide synthesis. A novel synthesis of peptides containing C-terminal glutamine, (xanthenyl) Bull Chem Soc Jpn 34, 739, 1961. 

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