American Stroke Association guidelines

Alteplase (rt-PA Activase) is an IV thrombolytic (fibrinolytic) that was approved for acute stroke treatment in 1996 based on the results of the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Trial.10 The current American Stroke Association guidelines include alteplase as the only Food and Drug Administration (FDA) approved acute treatment for ischemic stroke and strongly encourage early diagnosis and treatment of appropriate patients.11... 

Despite being listed in the official recommendation and guidelines for stroke management by the American Stroke Association, the American Heart Association, the American Academy of Neurology, and the American College of Chest Physi-... 

Adams HP, Jr., Adams RJ, Brott T, del Zoppo GJ, Furlan A, Goldstein LB, Grubb RL, Higashida R, Kidwell C, Kwiatkowski TG, Marler JR, Hademenos GJ. Guidelines fortbe early management of patients with ischemic stroke A scientific statement from the Stroke Council of the American Stroke Association. Stroke. 2003 34 1056-1083. 

Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke 2005 guidehnes update a scientific statement from the stroke Council of the American Heart Association/American Stroke Association. Stroke 2005 36 916-923. 

The American Heart Association/American Stroke Association (AHA/ ASA) Stroke Council guidelines for the management of acute ischemic stroke give grade A recommendations (i.e., evidence supported by data from randomized trials) to only two pharmacologic therapies (1) IV tissue plasminogen activator (alteplase) within 3 hours of onset and (2) aspirin within 48 hours of onset. Evidence-based reconnmendations for pharmacotherapy of ischemic stroke are given in Table 13-1. 

Goldstein, L.B., Bushnell, C.D., Adams, R.J., Appel, L.J., Braun, L.T., Chaturvedi, S., Creager, M.A., Culebras, A., Eckel, R.H., Hart, R.G., et al. Guidelines for the primary prevention of stroke a guideline for healthcare professionals from the american heart association/american stroke association. Stroke 42(2), 517-584 (2011)... 

The brain attack coalition (BAC) and more recently the American Heart Association have offered consensus guidelines for criteria designating a primary stroke... 

Biller J, FeinbergWM, CastaldoJE, etal, Guidelines for carotid endarterectomy a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 1998 29 554-562. 

Albers GW, Hart RG, Lutsep HL, Newell DW, Sacco RL. AHA Scientific Statement. Supplement to the guidelines for the management of transient ischemic attacks a statement from the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association. Stroke 1999 30 2502-251 I. 

On the basis of the NINDS trial and the previously reported IV rt-PA experience, rt-PA was approved in the United States, and its use was endorsed in consensus guidelines published by the American Heart Association Stroke Council [48,49] and the American Academy of Neurology [50] for treatment of acute ischemic stroke. 

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