Bupropion Amantadine

Dopamine-Stimulating Medications. A variety of drugs that increase the availability of dopamine have been studied in cocaine addicts including L-DOPA, bupropion, amantadine, and methylphenidate. In small uncontrolled trials, these have shown some benefit, but definitive studies have yet to be performed. In addition, some dopamine-stimulating medications (in particular, the stimulants like methylphenidate or the amphetamines) are themselves subject to abuse, though, of note, this is typically not a problem when they are prescribed to patients who do not have a history of substance abuse such as, for example, in the treatment of attention deficit-hyperactivity disorder. 

Shuster J. Benzodiazepines and glucose control mycophe-nolate mofetil-induced dyshidrotic eczema concomitant use of bupropion and amantadine causes neurotoxicity intra-articular steroids and acute adrenal crisis. Hosp Pharm 2000 35 489-91. 

DOPAMINERGICS AMANTADINE t CNS side-effects Additive effects Monitor more closely for confusion, gastrointestinal side-effects. Initiate therapy with bupropion at the lowest dose and t gradually. Manufacturers recommend avoiding co-administration of amantadine and memantine... 

Bupropion should be used with caution in patients taking levodopa or amantadine, as these agents can potentially enhance dopamine neurotransmission and be activating... 

Amphetamines 2-5 days Up to 2 weeks with prolonged or heavy use Many sympathomimetic amines such as pseudoephedrine, ephedra, phenylephrine, fenfluramine, and phentermine may cause positive results. Other drugs such as selegiline, chlorpromazine, trazodone, bupropion, and amantadine may cause false-positive results depending on the assay. 

DA agonists levodopa, bromocriptine, 1 pergolide, pramipexole 1 MAO-B inhibitor selegOine 1 AAAD inhibitor carbidopa I M blockers benztropine, trihexiphenidyl j COMT inhibitor tolcapone 1 Amantadine MAOIs phenelzine, tranylcypromine TCAs amitriptyline, imipramine, clomipramine SSRIs fluoxetine, paroxetine, sertraline Others bupropion, mirtazapine, trazodone, venlafaxine... 

---