Alzheimer etiology

Smith MA and Perry G (1998). What are the facts and artifacts of the pathogenensis and etiology of Alzheimer disease Journal of Chemical Neuroanatomy, 16, 35-41. 

Strunecka A, Patocka J (2003) Aluminofluoride Complexes in the Etiology of Alzheimer s Disease 104 139-180... 

Iqbal K, Swaab DF, Winblad B, Wisniewski HM. Alzheimer s disease and related disorders. Etiology, pathogenesis and therapeutics. Chichester (UK) John Wiley and Sons Ltd 1999. 

M. R. Farlow, Etiology and pathogenesis of Alzheimer s disease, Am. J. Health Syst. Pharm. 55 (Suppl. 2) (1998) S5-S10. 

To deal with the different disorders included in this section would be excessive therefore, we focus on dementia in Alzheimer s disease (AD]. Nevertheless, the less specific treatment options for AD are also complementary options to the usual treatment approaches for other forms of dementia or cognitive deficits in which etiological or more specific treatments may be useful (e.g., dementia in normal pressure hydrocephalus). 

The medicinal chemistry of Alzheimers is complicated by the fact that the etiology of this disease is still far from clear. Evidence points to an association with decreased levels of acetyl choline in the brain. Many of the drugs that have been introduced to date for treating this disease thus comprise agents intended to raise the deficient levels of that neurotransmitter by inhibiting the loss of existing acetylcholine due to the action of cholinesterase. A compound based on an indene that, perhaps surprisingly, inhibits that enzyme has been proposed for the treatment of Alzheimer s. Aldol condensation of piperidine aldehyde (4-2) with the indanone (4-1) from cyclization of 3,4-dimethoxycinnamic acid leads to the olefin (4-3). Catalytic reduction removes the double bond to afford donepezil (4-4) [3]. 

Moderately tone to most plants slightly toxic to mammals. Suggested as involved in the etiology of Alzheimer s disease and other neurologic diseases/"... 

Frolich L. and Floyer S. (2002). The etiological and pathogenetic heterogeneity of Alzheimer s disease. Nervenarzt 73 422 127. 

Gautrin D, Gauthier S. 1989. Alzheimer s disease Environmental factors and etiologic hypotheses. 

St. George-Hy slop P. 1995. Genetic determinants of Alzheimer disease. Etiology and Pathogenesis of Down Syndrome 139-145. 

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