Alpha to Oxygenated Carbon

Enzymes of the CYP51 family (sterol 14a-deme-thylases) catalyze the removal of the 14a-methyl 

The facts on the oxidation of the C32 aldehyde are remarkably similar to those seen for the aro-matase catalyzed reaction. The formate moiety that is expelled contains one dioxygen-derived oxygen atom and incorporates one oxygen and one hydrogen atom from the aldehyde precursor There is also a stereospecific loss of the syn 15a 

Some xenobiotic metabolizing enzymes, particularly CYP2B4, are also reported to be capable 

C5 tochrome P450s can also interact with aldehydes in a different way to generate the corresponding hydrocarbon and Hydrocarbons 

A reaction that involves cleavage of the C-C bond a to a phenol occurs in aflatoxin biosynthesis . 

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