Alpha2-adrenergic receptor

Gobert, A, Rivet, JM, Cistarelli, L, Melon, C and Millan, MJ (1997) Alpha2-adrenergic receptor blockade markedly potentiates duloxetine- and fluoxetine-induced increases in noradrenaline, dopamine and serotonin levels in the frontal cortex of freely moving rats. J. Neurochem. 69 2616-2619. 

Link, R. E., Desai, K., Hein, L. etal. Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science 273 803-805,1996. 

Finley JC, O Leary M, Wester D, MacKenzie S, Shepard N, Farrow S, Lockette W. A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress. J Appl Physiol 2004 96(6) 2231-9. 

Brede M, Philipp M, Rnaus A, et al. Alpha2-adrenergic receptor subtypes—novel functions uncovered in gene-targeted mouse models. Biol Cell. 2004 96 343-348. 

Davies, M. F., Tsui, J., Flannery, J. A., Li, X., DeLorey, T. M. Hoffman, B. B. (2004). Activation of alpha2 adrenergic receptors suppresses fear conditioning Expression of c-fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 29, 229-239. 

Alpha2-adrenergic receptor agonists (centrally acting drugs)... 

Rao AK, Willis J, Kowalska MA, WaditfogelY, Colman RW. Differential requirements for epinephrine induced platelet aggregation and inhibition of adenylate cydase. Studies in fimilial alpha2-adrenergic receptor defect Blood 1988 71 494-501. 

C. Garenc, et ah. The alpha2-adrenergic receptor gene and body fat content and distribution the HERITAGE family study. Mol. Med., 2002, 8, 88-94. 

Valet P, Pages C, Jeanneton O, Daviaud D, Barbe P, Record M, Saulnier-Blache JS, Lafontan M (1998) Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. J Clin Invest 101 1431-1438... 

FIGURE 58 Guanabenz lowers blood pressure by stimulating the central alpha2-adrenergic receptor, decreasing central sympathetic outflow, and thus decreasing peripheral vascular resistance. 

Guanfacine (1 mg/day at bedtime) is indicated in the management of hypertension. Clonidine, guanfacine, guanabenz, and methyldopa are centrally acting alpha2-adrenergic-receptor... 

Yohimbine, an alpha2-adrenergic-receptor-blocking agent has no medical indications. Urologists have used yohimbine in determining the nature of male erectile impotence and internists have used it successfully (18 mg/day) to treat impotence associated with vascular or diabetic origins. 

Karamanos, N.K. Lamari, F. Katsimpris, J. Gartaganis, S. Development of an HPLC method for determining the alpha2-adrenergic receptor agonist brimonidine in blood serum and aqueous humor of the eye, Biomed.Chromatogr., 1999,13, 86-88. 

Jewell-Motz, E.A. and Liggett, S.B., G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes,/. Biol Chem., 271,18082,1996. 

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