ALOX5 genotype

Fig. 10.2 ALOX5 genotype predicts anti-leu-kotriene response. Outcome of clinical trial of ABT-761, an ALOX5 inhibitor similar to Zileu-ton, stratified by genotype. Improvement in FEV] from pre-treatment baseline at 84 days of...

Drazen JM, Yandava CN, Dube L, SzCZERBACK N, HlPPENSTEEL R, PlLLARI et al. Pharmacogenomic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet 1999 22 168-170. 

Drazen, J., et al., "Pharmacogenetic Association Between ALOX5 Promoter Genotype and the Response to Anti-Asthma Treatment," Nat. Genet., 22, 168-170 (1999). 

Kalayci O, Birben E, Sackesen C, et al. (2006) ALOX5 promoter genotype, asthma severity and ETC production by eosinophils. Allergy. 61, 97-103. 

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