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ALOX5

Drazen JM, Yandava CN, Dube L, SzCZERBACK N, HlPPENSTEEL R, PlLLARI et al. Pharmacogenomic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet 1999 22 168-170. [Pg.55]

This hypothesis was investigated in a retrospective analysis of the response to an ALOX5 inhibitor, ABT-761, which is clinically similar to zileuton. In 221 patients with asthma who received either high-dose ABT-761 (n= 114) or placebo (n= 107] treatment, approximately 6% of asthmatic patients had no wild-type allele... [Pg.223]

Fig. 10.2 ALOX5 genotype predicts anti-leu-kotriene response. Outcome of clinical trial of ABT-761, an ALOX5 inhibitor similar to Zileu-ton, stratified by genotype. Improvement in FEV] from pre-treatment baseline at 84 days of... Fig. 10.2 ALOX5 genotype predicts anti-leu-kotriene response. Outcome of clinical trial of ABT-761, an ALOX5 inhibitor similar to Zileu-ton, stratified by genotype. Improvement in FEV] from pre-treatment baseline at 84 days of...
Drazen, J., et al., "Pharmacogenetic Association Between ALOX5 Promoter Genotype and the Response to Anti-Asthma Treatment," Nat. Genet., 22, 168-170 (1999). [Pg.103]

Manev H, Manev R. (2006) 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer s disease. Med Hypotheses. 66, 501-503. [Pg.374]

Kim SH, Choi JH, Holloway JW, et al. (2005) Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma differing contributions of ALOX5 polymorphism in Korean population. J Korean Med Sci. 20, 926-931. [Pg.374]

Kalayci O, Birben E, Sackesen C, et al. (2006) ALOX5 promoter genotype, asthma severity and ETC production by eosinophils. Allergy. 61, 97-103. [Pg.375]

Lipoxygenase (ALOX5) Leukotriene receptor antagonists Asthma response... [Pg.66]

The gene of 5-lipoxygenase (ALOX5) has been studied in relation to zileuton and montelukast altered drug response [28]. [Pg.206]

See other pages where ALOX5 is mentioned: [Pg.39]    [Pg.68]    [Pg.77]    [Pg.223]    [Pg.223]    [Pg.224]    [Pg.224]    [Pg.224]    [Pg.224]    [Pg.225]    [Pg.172]    [Pg.174]    [Pg.360]    [Pg.366]    [Pg.367]    [Pg.367]    [Pg.374]    [Pg.544]    [Pg.20]    [Pg.1609]    [Pg.343]    [Pg.632]    [Pg.635]    [Pg.35]    [Pg.96]    [Pg.211]    [Pg.19]    [Pg.18]   
See also in sourсe #XX -- [ Pg.37 , Pg.76 , Pg.223 ]



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ALOX5 genotype

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