Alosetron adverse effects

Flnvoxamine Increases alosetron levels and increase risk of adverse effects... 

Women had significantly greater responses than men. Constipation was the most commonly reported adverse effect of alosetron (49% compared with 13% in the placebo group). In a randomized, double-blind, placebo-controlled trial in 626 women with diarrhea-predominant irritable bowel syndrome, alosetron 1 mg bd was significantly more effective than placebo in controlling symptoms... 

Constipation was the most common adverse effect of alosetron (25% compared with 5% in the placebo group). 

Alosetron was withdrawn from the U.S. market in 2000 due to serious adverse effects including severe constipation and ischemic colitis that did not appear in the initial clinical trials. Its use is now limited to an FDA-approved restricted use program in lower initial doses, and requires extensive postmarketing surveillance. Results of these trials are necessary to definitively determine alosetron s true safety profile, especially with regard to its association with or causation of fatal ischemic colitis. 

D. Toxicity Adverse effects of ketanserin are those of alpha blockade and Hj blockade. The toxicides of ondansetron, granisetron, and dolasetron include diarrhea and headache. Dolasetron has been associated with QRS and QT prolongation in the ECG and should not be used in patients with heart disease. Alosetron caused significant constipation in some patients. 

Alosetron 1 mg twice daily for 2 days had no significant effect on the pharmacokinetics of a singie 1-mg dose of alprazolam in 12 heaithy subjects. No increase in adverse effects was noted with the combination. No speciai precautions therefore seem necessary on concurrent use. 

Constipation is the most frequent adverse event, with a higher incidence of transient constipation in alosetron-treated patients, typically occurring in the first month of treatment. Significant side effects noted with the use of alosetron include severe constipation, fecal... 

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