Iridium catalysis allylic substitution

Keywords Allylic substitution Asymmetric catalysis Heterocycles Iridium Phosphoramidite... 

With iridium catalysis, the -rr-allyl intermediate is attacked by the nucleophile at the more-substituted terminus. Again, the inclusion of a chiral ligand yields an optically active product (Scheme 9.66). 

A related iridium complex has been used for the decarbo)grlative radical allylation of aminoacids and phenylacetic acids that occurs smoothly at room temperature in the presence of Pd(PPh3)4, irradiating by white LEDs. The proposed scheme (Scheme 6) is based on dual catalysis. Ruthenium tris(phenanthroline) dichloride has been used for visible light catalysis of the mild amidation of ketoacids by ort/zo-substituted anilines using ozygen as terminal oxidant (Scheme 7) ... 

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