Allosterism and Regulation

Allosteric ( other site ) enzyme or binding proteins are proteins with multiple interacting sites. Allosteric proteins can exhibit one or both of two t3 es of allosterism  

Look at cooperativity/regulation curves for enzymes/binding proteins. Get two families of regulators  

So how to explain the cooperative behaviour of allosteric proteins Need to explain both kinds of effects. 

Two Important Models Symmetry Model of Allosterism and Sequential Model of Allosterism. 

In this model the subunits are each influenced by binding to other subunits, but change is step-wise rather ffian concerted. 

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