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Allosteric effectors of hemoglobin

Case Study The Discovery and Development of Allosteric Effectors of Hemoglobin... [Pg.462]

When erythrocytes circulate in underoxygenated tissue, release of 2,3-dipho-sphoglycerate (2,3-DPG) is increased. This release of 2,3-DPG lowers the affinity of hemoglobin for oxygen (2,3-DPG is an allosteric effector of hemoglobin). As a consequence, extraction of oxygen from blood by tissues is increased. Thus, PGK inhibition is a possible approach for treating cardiac and respiratory disorders. [Pg.233]

Glycerate-2,3-bisphosphate was encountered as an allosteric effector of hemoglobin. [Pg.892]

The Gd-DOTP chelate (Fig. 18) has been examined as a potential allosteric effector of hemoglobin [113]. Human hemoglobin is a tetrameric protein whose quaternary structure is affected by an allosteric effector. Binding of this low molecular weight species stabilizes the so-called T-form of hemoglobin, which is characterized by a low oxygen affinity, as opposed to the R-form, a very efficient... [Pg.153]

See other pages where Allosteric effectors of hemoglobin is mentioned: [Pg.462]    [Pg.463]    [Pg.465]    [Pg.467]    [Pg.469]    [Pg.469]    [Pg.471]    [Pg.473]    [Pg.475]    [Pg.477]    [Pg.479]    [Pg.219]    [Pg.29]    [Pg.565]    [Pg.423]    [Pg.954]    [Pg.652]    [Pg.192]    [Pg.110]    [Pg.51]   
See also in sourсe #XX -- [ Pg.421 , Pg.422 , Pg.423 ]

See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.386 , Pg.388 , Pg.389 , Pg.390 , Pg.391 , Pg.392 , Pg.393 ]



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Allosteric

Allosteric effectors

Allosterism

Effector

Hemoglobin allosteric effector

Hemoglobin allosterism

Of hemoglobin

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