Allografts decellularization

Meyer SR, Chiu B, Churchill TA, Zhu L, Lakey JR, Ross DB. Comparison of aortic valve allograft decellularization techniques in the ra.t. J Biomed Mater Res A 2006 79(2) 254-62. 

J.S. Choi, et al., Decellularized extracellular matrix derived from human adipose tissue as a potential scaffold for allograft tissue engineering, J Biomed Mater Res A 97 (2011) 292-299. 

Acellular nerve matrix allografts have also been observed as useful biomaterials for nerve regeneration [34]. These allografts preserve extracellular matrix (ECM) components and, therefore, mimic the ECM of peripheral nerves mechanically and physically. In this way, acellular nerve matrices aid in the reconstruction of the peripheral nerve. However, decellularization techniques, such as thermal deceUularization, can damage the ECM structure and fail to extract all cellular components leading to inflammation upon implantation [35]. 

ECM-derived molecules (eg, collagen, laminin, fibrin, fibronectin, andhyaluronan) instead of decellularized allografts are also used. For instance. Neurotube, NeuroGen,... 

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