Allergic airway inflammation eotaxin

JOSE, P.H., GRIFFITHS-JOHNSON, D.A., COLLINS, P.D., WALSH, D.T., MOQBEL, R TOTTY, N.F., TRUONG, O., HSUAN, J.J. WILLIAMS, TJ. (1994) Eotaxin a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. Journal of Experimental Medicine, 179, 881-887. 

Fulkerson, P.C., Fischetti, C.A., McBride, M.L., Hassman, L.M., Hogan, S.P. etal. (2006) A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proceedings of the National Academy of Sciences of the United States of America, 103, 16418-16423. 

Conroy, D. M., Humbles, A. A., Rankin, S. M., Palframan, R. T., Collins, P. D., Griffiths-Johnson, D. A., Jose, P. J., and Williams, T. J. (1997) The role of the eosinophil-selective chemokines, eotaxin, in allergic and non-allergic airways inflammation, in New Perspectives in Eosinophils. Role in Inflammation Associated with Allergy, Asthma and Parasitic Disease (Cordeiro, R., Moqbel, R., and Weller, P. F., eds.), Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil, pp. 183-191. 

Blockade of CCR3 represents a new therapeutic target to inhibit eosinophil accumulation in vivo and will be a valuable tool to ascertain the effects of eosinophil infiltration on airway function and also to determine the role of eotaxin in recruiting basophils and Th2 lymphocytes, which also express CCR3, in allergic inflammation. 

---