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Allergen-induced airway responsiveness mechanism

Elwood W, Lotval JO, Barnes PJ, Fan Chung K (1992) Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitised Brown Norway rats. Am Rev Resp Dis 145 1289-1294 Elwood W, Barnes PJ, Sakamoto T, Fan Chung K (1993) Allergen-induced airway hyperresponsiveness in Brown Norway rat role of parasympathetic mechanisms. J Appl Physiol 75 279-284... [Pg.24]

The mechanism of allergen-induced increase in airway responsiveness is uncertain. Animal studies suggest the need for polymorphonuclear leukocytes (43). The relationship of this to the LAR, the relationship of the LAR to allergen-induced airway inflammation (see below), and the correlation between airway responsiveness and airway eosinophilia (44) have led to the hypothesis that allergen-induced increase in airway responsiveness is somehow caused by airway inflammation. In fact, until recently, measurement of allergen-induced increases... [Pg.195]


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See also in sourсe #XX -- [ Pg.195 ]




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