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Allenic sulphones reactions

The reaction of enamines and imines with acrylamide results in aza-annulation120,121. Other electrophilic alkenes which have been used to alkylate enamines and the products used in hetero- or carbocyclic synthesis include ethyl / -nitroacrylate122, where reaction occurs beta to the nitro not the ester group, 2-(phenylseleno)prop-2-enenitrile [CH2 = C(SePh)CN]123,124, phenyl a-phenylselenovinyl sulphone [CH2 = C(SePh)-S02Ph]124 and phenyl a-bromovinyl sulphone124. An electrophilic allene, phenylsulpho-nylpropadiene, has also been used to alkylate enamines125 (Scheme 44). [Pg.760]

Alkylation of the sulphone (111) with Bu"Li-Me3SiCH2l gave the /8-silyl-sulphone (112) which with Bu NF gave ° 3-methylene-5a-cholestane (113). Alkenyl sulphoxides, such as (114), were reduced to the alkenyl sulphides, without double-bond isomerization, using EtNlgBr-Cul " and the terminal allene (115) was prepared by treatment of (114) with LTMP. Reaction of... [Pg.230]

The well-established synthesis of allenes by the substitution reaction of cuprates with propargylsulphonates has been applied to the preparation of the a-allenic amines (268), by the addition of the new cuprate (266) to the sulphonates (265). Subsequent hydrolysis of the imine (267) with oxalic acid gives the amines (268), and although yields are only moderate (20—50%), the method has the... [Pg.39]


See other pages where Allenic sulphones reactions is mentioned: [Pg.943]    [Pg.1196]    [Pg.209]    [Pg.151]    [Pg.62]    [Pg.214]    [Pg.69]    [Pg.57]    [Pg.75]   
See also in sourсe #XX -- [ Pg.787 , Pg.788 , Pg.798 , Pg.807 ]




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Allenes reactions

Allenic sulphones

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