2-alkylidene-4- hydroxyalkanoates and

Application of Allylboronates in the Synthesis of 2-Alkylidene-4-Hydroxyalkanoates and 2-Alkylidene-4-Aminoalkanoates... 

In 2001, Ballini and coworkers [46] demonstrated that convenient method for the preparation of 2-methylene-4-nitroalkanoates 56 relies on a reaction between ethyl 2-(bromomethyl)acrylate 55a with selected nitroalkanes 51 (Scheme 4.14). Originally formed adducts 56 were transformed into target Y-substituted-a-alkylidene-y-lactones 50a in a sequence of reactions involving oxidation of the nitro group to carbonyl group by means ofa Nef reaction, subsequent reduction of4-03K>aIkanoates 57 obtained and acid-mediated cyclization of 4-hydroxyalkanoates. 

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