Alkyl-1,8-naphthyridines oxidation

The naphthyridines undergo N-alkylation reactions as expected. Thus, N-6 and N-7 are methylated first in 1,6- and in 1,7-naphthyridine, respectively. The quaternary iV-methyl salts are oxidized by potassium ferricyanide to afford the JV-methyl-a-one derivatives (95-98).54-56 The kinetics of... 

Note 1,5-Naphthyridinecarboxylic acids have been made by primary synthesis (see Chapter 1) and by oxidation of alkyl-1,5-naphthyridines (see Section 2.2.2). The remaining routes involving oxidation of aldehydes or hydrolysis of esters are exemplified here. 

These aldehydes have been made by oxidation of alkyl-1,5-naphthyridines (see Section 2.2.2). 

Monographs on Contemporary Heterocyclic Chemistry and quinoline chemistry have appeared. The latter work contains reviews on alkyl- and aryl-quinolines, Reissert compounds and related dihydroquinolines, and quinoline N-oxides. The chemistry of quinolizines, 1, 7-naphthyridines, azaphenalenes, 2... 

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