Alkenes heterocyclic scaffolds

Stowers KJ, Fortner KC, Sanford MS (2011) Aerobic Pd-catalyzed sp3 C-H olefination a route to both N-heterocyclic scaffolds and alkenes. J Am Chem Soc 133(17) 6541-6544... 

Hypervalent iodine(III) mediated/catalyzed intramolecular oxidative C-H bond functionalization of (hetero)arenes and alkenes has been widely applied in the synthesis of several biologically active heterocyclic scaffolds. This intramolecular oxidative C-H bond functionalization reaction leads to the formation of carbon-carbon and carbon-heteroatom bonds in an efficient manner. Of all bond formation reactions, C-N bond annulations have been exploited most and are of immense... 

Carboamination Reactions of Alkenes Synthesis of Diverse Heterocyclic Scaffolds... 

Stereoselective Synthesis of 3,5-Disubstituted Morpholines After successful use of the carboamination reaction of amino alkenes for the synthesis of pyrrolidines, pyrazolidines, and piperazines, the same group reported on the synthesis of another important heterocyclic scaffold morpholine. Morpholines are also widely applicable and present in various biologically important natural and... 

Incorporation of the new catalysis concept and N-heterocyclic carbene catalysis into multicatalytic systems emerged as a new direction to build up a complex scaffold such as those often found in natural products. Liu et al. developed an enantioselective Diels-Alder reaction via trienamine catalysis of indole-2,3-quinodimethane and activated alkenes. More recently, they combined this Diels-Alder process with N-heterocyclic carbene catalysis for the rapid generation of chiral cyclopentanone-fused tetrahydrocarbazoles with diverse substitution [30]. Mechanistically, with the... 

Enyne cycloisomerizations are metal promoted rearrangements in which a substrate bearing an alkene and an alkyne unit is isomerised into a cyclic moiety, with no (formal) loss or gain of any atoms. They represent useful catalytic methods for the synthesis of carbo- and heterocycles of increased structural complexity, from relatively simple, acyclic starting materials. These reactions have attracted much attention mainly because of the diversity of molecular scaffolds that they produce. 

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