Alkaloids of Aconitum karakolicum Rapes

Alkaloids of Aconitum karakolicum Rapes.—Workers at Tashkent have completed the elucidation of the structure of aconitine (C34H47N012 m.pt 195—197 °C),28 isolated from the tubers and aerial parts of plants collected in the Terskei Ala-Tau mountain range. Aconitine (55), napelline (70), songorine (71), and the aporphine alkaloid isoboldine were also isolated from the tubers. Aconitine was assigned structure (72) from chemical and H and 13C n.m.r. and mass-spectral analyses. Alkaline hydrolysis of (72) afforded benzoic acid and the amino-alcohol aconifidine 

Alkaloids of Aconitum kusnezojfii Reichb.—Researchers in the Peoples Republic of China have reported studies on the alkaloids of Aconitum kusnezojfii Reichb. that had been collected in Inner Mongolia.29 The pharmacological effects of extracts of these plants were studied in several animal systems.30 The known alkaloids aconitine (55), mesaconitine (56), hypaconitine (57), and deoxyaconitine (79) were identified on the basis of comparison of their physical and chemical properties with those of authentic samples. In addition, a new base, beiwutine (C33H45N012 m.pt 196—198 °C), was reported. This base formed a perchlorate salt (m.pt 255—257 °C) and a tetra-acetate derivative (m.pt 242—244 °C). From the H and 13C n.m.r., i.r., and mass-spectral data, structure (80) was proposed for beiwutine. 

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