Alkaloids of Aconitum karakolicum

Alkaloids of Aconitum karakolicum.—Yunusov and co-workers have published the full paper on the structure elucidation of 12-acetylnapelline (59) [C24H35NO4 m. pt. 205—206 °C] in further studies of the alkaloids of A. karakolicum cf. Vol. 8, p. 236). These plants were collected in the Kirghiz S.S.R. Also isolated from the epigeal parts were aconitine (21), aconitine (60), songorine (61), napelline (62), and phenyl-2-naphthylamine. 

Formation of the Oxazolidine and Thiazolidine Ring in C20 Diterpenoid Systems.—A convenient method for the construction of oxazolidine and thiazolidine rings from the imine-containing diterpenoids has been reported. Treatment of the imine, e.g. lindheimerine (63), with ethylene oxide in glacial acetic acid or with excess neat ethylene sulphide gave the corresponding oxazolidine [e.g. ovatine (64)] and thiazolidine [e.g. (65)], respectively, in yields of 90—98%. 

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Alkaloids of Aconitum karakolicum 12-Acetylnapelline.—In further studies of the alkaloid fraction of the aerial parts of Aconitum karakolicum, Yunusov and co-workers44 identified songorine (95), napelline (96), and a new base, C24H35NO4,... 

Alkaloids of Aconitum karakolicum Rapes.—Workers at Tashkent have completed the elucidation of the structure of aconitine (C34H47N012 m.pt 195—197 °C),28 isolated from the tubers and aerial parts of plants collected in the Terskei Ala-Tau mountain range. Aconitine (55), napelline (70), songorine (71), and the aporphine alkaloid isoboldine were also isolated from the tubers. Aconitine was assigned structure (72) from chemical and H and 13C n.m.r. and mass-spectral analyses. Alkaline hydrolysis of (72) afforded benzoic acid and the amino-alcohol aconifidine... 

The isomerization of atisine to isoatisine and the conformational analysis of rings E and F of atisine, veatchine, and related alkaloids have been studied by n.m.r. spectroscopy. 12-O-Acetylnapelline is a new alkaloid which has been isolated from Aconitum karakolicum. 

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