Historical perspectives alkaloids

This chapter is an historical perspective with selected examples from our own laboratory, first at the University of Munich, and now at the Leibniz Institute of Plant Biochemistry in Halle, that reflect the changes in how we define and exploit sequence-based approaches to alkaloid biosynthesis gene identification. ... 

K. Wiesner, Some Highlights in the Structural and Synthetic Chemistry of the Aconite Alkaloids. A Personal Historical Perspective, Tetrahedron, 1985, 4 , 485. 

The bisindole alkaloids are clearly closely associated with MDR from both historical and structural perspectives. The clinical relevance of this mechanism of drug resistance has not been unambiguously established however, the tissue-specific expression of P-gp has been noted for several normal as well as malignant tissues (105). Therefore, the natural resis-... 

The fourth chapter Quinazoline Alkaloids and Related Chemistry by Shoji Eguchi provides a perspective review focusing on developements of the synthetic methodologies and their synthetic applications. A brief historical background, aza-Wittig methodology, microwave-assisted synthesis, solid-phase... 

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