Alkaline hypobromite procedure

In the determination of chromium (Table VI), none of the methods studied gave very good results. The accuracy of the permanganate (6) and alkaline hypobromite (7) procedures were only fair, and the precision of the permanganate method was rather poor. 

This method also has been applied with advantage to the production of alicyclic monoamines from monoamides. The isomeric 0-, m-, and p-hexahydrotoluamides have been converted through the urethans to the corresponding aminomethylcyclohexanes in approximately 70% yield. Similarly camphane-4-carboxamide has been converted to 4-aminocam-phane (56% yield). Although many conversions of alicyclic monoamides to alicyclic amines have been carried out by the usual procedure (aque-ou alkaline hypobromite) the yields have not been reported. 

Amides react with alkaline hypochlorite or hypobromite solutions to form primary amines having one less carbon atom. The reaction involves the hydrolysis of an isocyanate, which is seldom isolated. Isocyanates are also intermediates in the Curtius and Lossen rearrangements (methods 447 and 448). Although diese methods have a common mechanism and intermediate, they involve three separate and distinct types of starting materials and are, therefore, treated individually. A comparison of these reactions has been made. A detailed discussion of the Hofmann reaction, which includes conditions, typical procedures, and compounds prepared thereby, has been presented. ... 

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