Alkaline hydrolysis of 4-nitrophthalimide

Khan, M.N., Abdullah, Z. Kinetics and mechanism of alkaline hydrolysis of 4-nitrophthalimide in the absence and presence of cationic micelles. Int. J. Chem. Kinet. 2001, 33, 407 14. 

Khan, M.N., Ismail, E. Effects of nonionic and mixed cationic-nonionic micelles on the rate of alkaline hydrolysis of 4-nitrophthalimide. J. Colloid Interface Sci. 2001, 240(2), 636-639. 

Another experimental example, which could demonstrate the importance of the so-called empirical criteria described in the beginning of this section, is the kinetic study of alkaline hydrolysis of 4-nitrophthalimide (NPT) in the absence and presence of cationic micelles (cetyltrimethylammonium bromide, CTABr micelles) at 35°C. The pH-independent and pH-dependent rate of alkaline hydrolysis of NPT in the absence and, presumably, in the presence of micelles involve the reaction of HO with nonionized (SH) and ionized (S ) NPT, respectively Pseudo-first-order rate constants (kobs) for hydrolytic cleavage of NPT at 0.01-M NaOH, 35°C and varying total concentrations of CTABr ([CTABrlx), as listed in Table 7.14, have been treated with Equation 7.76 where [D ] = [CTABrlx - CMC, Ks is CTABr micellar binding constant of NPT, k and k, represent pseudo-first-order rate constants for hydrolysis of NPT in the aqueous pseudophase and micellar pseudophase, respectively. The nonlinear least-squares calculated values of k, . Kg, and least squares (Sd ) are shown in Table 7.14. The values of k ai are comparable with the corresponding kobs values within the domain of the acceptable residual errors dj (Table 7.14). 

---