Bisphosphines aliphatic

Melhado et al. [100] reported an enantioselective Au(l)-catalyzed Mannich reaction employing spiro bisphosphines ligands (i )-21b, which provides direct access to aliphatic and aromatic a,p-diamino acid derivatives in high diastereo- and enantioselectivities (Scheme 37). 

Aluminium-BINOL-based complexes have also been shown to be highly selective bifunctional asymmetric cyanation catalysts. For example the bisphosphine oxide (6.65) developed by Shibasaki and coworkers catalyses the cyanation of both aromatic and aliphatic aldehydes with ees ranging from 83-98%. ... 

The ability to catalyze the asymmetric hydrogenation of aliphatic ketones provides an opportunity to extend the scope of these reactions to the dynamic kinetic resolution of ketones that contain a stereocenter in the enolizable a-position. The catalysts containing bisphosphine and diamine ligands are activated by base, and the base used to activate the metal catalyst can also catalyze the racemization of the ketone. An example of such a process is shown in Equation 15.76. ... 

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