Alio cholic acid

Alio cholic acid 3 -Hydroxy-5-cholenoic acid t(0.5-8.0) n (87) ... 

Until recent years, bile salts were considered to be exclusively 5 8 steroids. The first recognition of the occurrence of 5a or alio bile salts came from the studies of Anderson and Haslewood (165) who synthetized allocholic acid and identified it as a previously unidentified naturally occurring acid from fish bile. The earliest isolation of allocholic acid appears to have been that by Ohta from the bile of the Gigi fish (166). Since that time allocholic acid has been isolated from the bile of a large number of fishes, birds, and, to a smaller extent, mammals (4). It has also been detected in human feces (121). Allocholic acid may be prepared from cholic acid by allomerization of the 6,7-ketol in hot alkali (165) or by treatment of the 3-keto acid with Raney nickel in boiling isopropyl benzene (167). 

The origin of alio bile acids from cholestanol is clearly established (121, 36,28,122,40,123). After separation of two unidentified biliary acids similar to, but not identical with, cholic and chenodeoxycholic acids, Harold et al. 

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