Alio bile salts

The common bile acids and salts possess a characteristic molecular structure shown schematically for sodium cholate in Fig. 1 [7]. In contrast to the all irons arrangement of the alicyclic ring systems in alio bile salts, a crucial feature of the... 

Until recent years, bile salts were considered to be exclusively 5 8 steroids. The first recognition of the occurrence of 5a or alio bile salts came from the studies of Anderson and Haslewood (165) who synthetized allocholic acid and identified it as a previously unidentified naturally occurring acid from fish bile. The earliest isolation of allocholic acid appears to have been that by Ohta from the bile of the Gigi fish (166). Since that time allocholic acid has been isolated from the bile of a large number of fishes, birds, and, to a smaller extent, mammals (4). It has also been detected in human feces (121). Allocholic acid may be prepared from cholic acid by allomerization of the 6,7-ketol in hot alkali (165) or by treatment of the 3-keto acid with Raney nickel in boiling isopropyl benzene (167). 

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