Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Algorithms, protein design

D. B. Gordon, S. L. Mayo. Branch-and-terminate a combinatorial optimization algorithm for protein design. Structure Fold Des. 1999, 7, 1089-1098. [Pg.242]

Docking a ligand into a protein pocket is a combinatorial problem. Algorithms are designed to cover the space of interactions as exhaustively as possible to avoid... [Pg.275]

D. T. Jones, Protein Sci., 3, 567 (1994). De Novo Protein Design Using Pairwise Potentials and a Genetic Algorithm. [Pg.70]

Elimination Algorithms Make Large-Scale Protein Side-Chain Stmctnre Prediction Tractable Implications for Protein Design and Structural Genomics. [Pg.165]

Desjarlais and Handel have used a GA to design the hydrophobic core of proteins. They encoded the problem using a symbolic alphabet that specified residue types and residue conformations (which were picked from a rotamer library). The fitness function evaluated the steric energy of the encoded core. The algorithm was able to reproduce known core sequences and two variants of phage 434 cro protein, designed by the program, proved as stable as the native structure. [Pg.1132]

See other pages where Algorithms, protein design is mentioned: [Pg.66]    [Pg.18]    [Pg.428]    [Pg.82]    [Pg.97]    [Pg.105]    [Pg.80]    [Pg.208]    [Pg.5539]    [Pg.5549]    [Pg.33]    [Pg.2469]    [Pg.2473]    [Pg.126]    [Pg.259]    [Pg.356]    [Pg.231]    [Pg.98]    [Pg.28]    [Pg.5538]    [Pg.5548]    [Pg.438]    [Pg.548]    [Pg.290]    [Pg.401]    [Pg.401]    [Pg.122]    [Pg.1134]    [Pg.2170]    [Pg.2176]    [Pg.2179]    [Pg.2210]    [Pg.2219]    [Pg.2254]    [Pg.294]    [Pg.495]    [Pg.678]    [Pg.683]    [Pg.408]    [Pg.5]    [Pg.365]   
See also in sourсe #XX -- [ Pg.428 ]



SEARCH



Design algorithms

Designer proteins

Protein design

© 2024 chempedia.info